13 Jan Write a differential diagnosis of a

Week 1: Altered Immune System and Altered Inflammatory Response

– Discussion Part One

This week’s graded topics relate to the following Course Outcomes (COs).

1 Analyze pathophysiologic mechanisms associated with selected disease states. (PO 1)

2 Differentiate the epidemiology, etiology, developmental considerations, pathogenesis, and clinical and laboratory manifestations of specific disease processes. (PO 1)

3 Examine the way in which homeostatic, adaptive, and compensatory physiological mechanisms can be supported and/or altered through specific therapeutic interventions. (PO 1, 7)

6 Distinguish risk factors associated with selected disease states. (PO 1)

5 Describe outcomes of disruptive or alterations in specific physiologic processes. (PO 1)

6 Distinguish risk factors associated with selected disease states. (PO 1)

7 Explore age-specific and developmental alterations in physiologic

and disease states. (PO 1, 4)

Discussion

Discussion Part One (graded)

John is a 19-year-old college football player who presents with sneezing, itchy eyes, and nasal congestion that worsens at night. He states that he has a history of asthma, eczema and allergies

to pollen. There is also one other person on the football team that has similar symptoms. His vitals are BP 110/70, P 84, R 18, T 100 F. Write a differential of at least five (5) possible items from the most likely to less likely. For each disease include information about the epidemiology, pathophysiology and briefly argue why this disease fits the presentation and why it might not fit the presentation

Week 1: Altered Immune System and Altered Inflammatory Response – Discussion

Part Two

A patient has been admitted into the emergency room that was in the passenger side of a car that collided with another car head on. The patient is pale, barely conscious and has a weak and thready pulse. An IV is started. The vitals are BP 80/50, P 140, T 96.0 and R 26. As the team fights to keep the patient alive they have to remove the spleen. Blood is given but it has been mistyped. A transfusion reaction occurs. Describe the type of hypersensitivity reaction that has occurred and discuss the molecular pathophysiology of the specific type of hypersensitive reaction you have chosen.

In the event that this patient survived the car accident and the transfusion reaction which organs are most likely to be damaged and why?

Week 1: Altered Immune System and Altered Inflammatory

Response – Discussion Part Three

This week’s graded topics relate to the following Course Outcomes (COs).

1 Analyze pathophysiologic mechanisms associated with selected disease states. (PO 1)

2 Differentiate the epidemiology, etiology, developmental considerations, pathogenesis, and clinical and laboratory manifestations of specific disease processes. (PO 1)

3 Examine the way in which homeostatic, adaptive, and compensatory physiological mechanisms can be supported and/or altered through specific therapeutic interventions. (PO 1,

4 Distinguish risk factors associated with selected disease states.(PO 1)

5 Describe outcomes of disruptive or alterations in specific physiologic processes. (PO 1)

6 Distinguish risk factors associated with selected disease states. (PO 1)

7 Explore age-specific and developmental alterations in physiologic and disease states. (PO 1, 4)

Discussion

A 44-year-old patient presents with lump in the chest of approximately 2 cm in diameter. There is a slight dimple over the location of the lump and when the lump is manipulated it seems to be attached to the surrounding tissue. A lumpectomy is performed and the mass is sent to pathology. The pathology report comes back and the mass is confirmed to be an estrogen receptor negative, a progesterone receptor negative and a her2/neu receptor positive breast cancer.

What are some of the risk factors for breast cancer?

What tumor suppressor genes are associated with breast cancer?

What tumor oncogenes are associated with breast cancer?

Compare and contrast tumor suppressor genes from oncogenes?

Week2

Week 2: Respiratory Disorders and Alterations in Acid/Base Balance,

Fluid and Electrolytes – Discussion Part One

This week’s graded topics relate to the following Course Outcomes (COs).

Analyze pathophysiologic mechanisms associated with selected disease states. (PO 1)

Differentiate the epidemiology, etiology, developmental considerations, pathogenesis, and clinical and laboratory manifestations of specific disease processes. (PO 1)

Examine the way in which homeostatic, adaptive, and compensatory physiological mechanisms can be supported and/or altered through specific therapeutic interventions. (PO 1, 7)

Distinguish risk factors associated with selected disease states. (PO1)

Describe outcomes of disruptive or alterations in specific physiologic processes. (PO 1)

Distinguish risk factors associated with selected disease states. (PO1)

Explore age-specific and developmental alterations in physiologic and disease states. (PO 1, 4)

Discussion Part One (graded)

A five-month-old Caucasian female is brought into the clinic as the parent complain that she has been having ongoing foul-smelling , greasy diarrhea. She seems to be small for her age and a

bit sickly but, her parent’s state that she has a huge appetite. Upon examination you find that

the patient is wheezing and you observe her coughing.

Write a differential diagnosis of at least five (5) disorders and explain why each might be

a possibility and any potential weaknesses of each differential.

Why is it that the later in age this disease manifest itself, the less severe the disease is?

What tests would you run to clarify your differential and potentially come to a definit