10 Jul A useful method for assessing the extent of the partitioning of a
A useful method for assessing the extent of the partitioning of a drug between the bloodstream and body fat is to determine the infinite dilution partition coefficient for the drug between water and n-octanol: Kdrug = xdrug in n-octanol-rich phase / xdrug in water-rich phase For a drug 3-(4-ethyl phenyl)propanoic acid (the structure is below), a. Use UNIFAC to determine the mutual solubility of water + n-octanol at the body temperature 37°C. b. Use UNIFAC to determine the infinite dilution partition coefficient at the body temperature 37°C. c. Will the drug stay in the bloodstream or move into fatty body parts?
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