15 Aug Please Read Attached Files For instructions!!For Project 1 y
Please Read Attached Files For instructions!!For Project 1 you are assigned the following article about Ebola for Part 4 Discussion of the science of a recent research study on the pathogen or disease it causes: NIAID (2016, February 25) News: Experimental Ebola Antibody Protects Monkeys. National Institute of Allergy and Infectious Diseases (NIAID). Retrieved from https://www.niaid.nih.gov/news-events/experimental-ebola-antibody-protects-monkeys You are not expected to cover or understand everything in the article. Focus on the experiment in nonhuman primates. I.Rationale: In a paragraph to introduce the study briefly describe the reason for testing the monoclonal antibody, mAb114 as a possible treatment for Ebola infection.You want to include the source of the antibody and what neutralizing antibodies are (see sources cited below). II.Include in your summary for Part 4a: a.Describe the purpose and hypothesis of experiment in nonhuman primates. [Hint: Including “will” in the title is often the hypothesis.] b. Based on the hypothesis write a prediction (If [hypothesis] and [method to test – the independent variable(s)], then [outcome measure – the dependent variable(s)]). state the independent and dependent variables, controlled variable and explain as related to their definitions and purpose in a study or experiment as per instructions for 4a in What to Include in Your Report. III. Include in your summary for Part 4b a. Approach (Experimental Design) In a flow chart outline the experimental design for assessing the effect of sofosbuvir in neonatal mice. The purpose is to help someone not reading the scientific article know what was done and to follow your discussion and summary of the study.State which group is the control group, whether a positive or a negative control group and how it is used as a control in the experiment.In a table summarize the percent of animals surviving after infection (include number tested in each group). Describe what the results showBriefly describe the findings about how the antibody neutralizes the Ebola virus. Results IV.Parts 4c, 4d, and 4e as per the instructions for “What to Include in Your Report”. The antibody is now in clinical trials. V. Some terms to explain include: antibodies, monoclonal antibody, neutralizing antibody, therapeutic, About neutralizing antibodies see Figure 18.7 and related description in: Parker, N., Schneegurt, M., Thi Tu, A.-H., Lister, P., & Forster, B. M. (2016). 18.1 Overview of Specific Adaptive Immunity in Microbiology. Houston: OpenStax. Retrieved from https://openstax.org/details/books/microbiology
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